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杨飞
2023-06-16 16:59  

杨飞,男,教授、博士生/硕士生导师,研究方向主要聚焦“典型环境污染对人群的健康危害及其机制研究”。曾任南华大学衡阳医学院人才培养办副主任及研究生院副院长,现任南华大学公共卫生学院院长。20086月毕业于东南大学公共卫生学院预防医学系,获医学学士学位。20088-20117月硕博连读于东南大学公共卫生学院劳动卫生与环境卫生学系,获医学博士学位,20118-20128月博士联合培养于美国宾夕法尼亚州立大学土木与环境工程学院。20143月起在中南大学湘雅公共卫生学院从事教学与科研工作(2014年至2018年中南大学湘雅公共卫生学院流行病学与统计学师资博士后)。2015年破格晋升副教授,现任南华大学教授。湖南省青年骨干教师,“湖南省优青获得者”,“生态健康与人类重要疾病防控”湖南省高校重点实验室副主任,“水环境与农产品安全”和“典型环境污染与健康危害”湖南省重点实验室骨干成员,南华大学“高层次人才(学科拔尖人才)”。以第一作者或者通讯作者发表ESI论文60篇,JCR126篇,JCR215篇。ESI1%)高被引论文5篇,影响因子10论文8篇。自然指数(NI)期刊论文2篇,热点论文ESI0.1%2篇。分别发表于Lancet (IF= 202.731)Environmental Science and Technology (IF= 11.357)Water ResearchNI自然指数期刊,IF=13.4)、Journal of Hazardous Materials (IF=14.224)Environment International (IF=13.352)Bioresource Technology (IF=11.889)Science of the Total Environment (IF=10.753)Environmental Pollution (IF=9.988)Chemosphere (IF=8.943)Ecotoxicology and Environmental SafetyIF=7.129授权专利5项,其中发明专利4项。主持国家自然科学基金2项,湖南省自然科学基金优秀青年项目1项,湖南省重点研发计划项目子课题3项;湖湘青年科技创新人才项目1项;博士后特别资助1项,中南大学猎英人才和创新驱动人才项目各1 项。第一发明人获得发明专利2项,实用新型专利2项。担任了全国环境诱变剂学会委员,湖南省流行病学专业委员会常务委员、湖南省预防医学会肥胖防治专业委员会副主委、Journal of Toxicology and Environmental HealthSCI期刊编委、《环境与职业医学》青年编委和《Toxins》客座主编。

近三年主持的科研项目

1. 湖南省科学技术厅, 湖南省重点研发项目(2022SK2089),洞庭湖典型污染物的综合防治技术, 2022/01- 2023/1240, 主持;

2. 省部级一般科研项目,省科技厅立项项目,《湖湘青年科技创新人才项目》(2021RC3107)2021/09-2024/0850万,主持;

3. 国家自然科学基金面上项目,基于转录组学和蛋白质组学解析Sphingopyxis   sp. YMCD对微囊藻毒素的代谢解毒机理(81773393),2018/01-2021/1260万,主持;

4. 国家青年自然科学基金项目,MC-LTH1降解微囊藻毒素的机理及降解产物的肝细胞毒性研究(81502787),2016/01-2018/1222.8万,主持;

5. 湖南省自然科学基金优秀青年项目,多组学联合探讨微生物解毒MC-LR的途径与分子机制,2020/01-2022/1220万,主持;

6. 湖南省重点研发计划项目,炎症性肠病综合防治关键技术研究(2019SK2041),2019/10-2021/10300.0万,主持(子课题 120万)(医学和生态环境等学科交叉融合);

7. 中南大学创新驱动项目,微生物解毒典型污染物的效果及机制研究,2018/1-2019/1262.0万,主持;

8. 中南大学猎英人才计划,环境新兴有机污染物的监测与防治,2015/10-2019/1050.0万元,主持;

9. 湖南省重点研发计划项目,基于微生物组学的农业环境污染防治与生态修复技术(2018WK2012),2019/01-2020/1220.0万,主持(子课题);

10. 湖南省自然科学基金青年基金,土著细菌Bordetella sp.对微囊藻毒素的降解作用与机制研究(2016JJ3166),2016/01-2018/125.0万,主持;

11. 中国博士后科学基金特别资助,土著细菌降解微囊藻毒素机制及降解产物的肝毒性研究(2016T90766),2016/06-2017/1215.0万,主持;

12. 国家科技基础性工作专项项目,重金属污染区人体镉等生物效应剂量与早期损害常数调查(2015FY111100),2015/01-2018/12,参与;

13. 国家重点研发计划精准医学研究项目,华中区域常见慢性非传染性疾病前瞻性队列研究(2016YFC0900800),2016/07-2020/12,参与。



3年发表部分论文

1. Jia Wei, Pengji Zhou, Jiajia Zhang, Tangjian Peng, Jiayou Luo, Fei Yang* (通讯作者). Biodegradation of MC-LR and its key bioactive moiety Adda by Sphingopyxis sp. YF1: Comprehensive elucidation of the mechanisms and pathways. Water Res. 2023;229:119397. JCR1区,IF 13.4,自然指数期刊,水环境领域排名第一期刊)

2. Shuidong Feng, Shuxiang Deng, Yan Tang, Ying Liu, Yue Yang, Shuaishuai Xu, Peng Tang, Yao Lu, Yanying Duan, Jia Wei, Geyu Liang, Yuepu Pu, Xiang Chen, Minxue Shen*, Fei Yang* (通讯作者). Microcystin-LR Combined with Cadmium Exposures and the Risk of Chronic Kidney Disease: A Case-Control Study in Central China. Environ Sci Technol. 2022;56(22):15818-15827.JCR1区,IF 11.3,自然指数期刊)

3. Yue Yang, Hui Wang, Xiaoyan Wang, Ling Chen, Wenya Liu, Danping Cai, Shuxiang Deng, Hanyu ChuYing Liu, Xiangling Feng, Jihua Chen, Mengshi Chen, Chengkun Wang, Ran LiuYuepu Pu, Zhen Ding, Deliang Cao, Dingxin Long, Yi Cao, Fei Yang* (通讯作者). Long-term environmental levels of microcystin-LR exposure induces colorectal chronic inflammation, fibrosis and barrier disruption via CSF1R/Rap1b signaling pathway. J Hazard Mater, 2022, 440: 129793.JCR1区,IF 14.2,自然指数期刊)

4. Fei Yang* (第一兼通讯作者), Feiyu Huang, Hai Feng, Jia Wei, Isaac Yaw Massey, Geyu Liang, Fang Zhang, Lihong Yin, Sam Kacew, Xian Zhang*, Yuepu Pu*. A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium. Water Research, 2020, 174: 115638. JCR1区,IF 13.4,自然指数期刊,水环境领域排名第一期刊)

5. Danping Cai, Jia Wei, Feiyu Huang, Hai Feng, Tangjian Peng, Jiayou Luo, Fei Yang* (通讯作者). The detoxification activities and mechanisms of microcystinase towards MC-LR. Ecotoxicology and environmental safety, 2022, 236: 113436.JCR1区,IF 7.1,自然指数期刊)

6. Jia Wei, Xian Xie, Feiyu Huang, Lin Xiang, Yin Wang, Tongrui Han, Isaac Yaw Massey, Geyu Liang, Yuepu Pu, Fei Yang* (通讯作者). Simultaneous   Microcystis algicidal and microcystin synthesis inhibition by a red pigment   prodigiosin. Environmental Pollution, 2020, 256, 1113444.JCR1区,IF 9.9,高被引论文,本科生为第一作者)

7. Xian Zhang *, Xinyu Ye , Lv Chen , Hongbo Zhao *, Qiwei Shi, Yunhua Xiao , Liyuan Ma , Xinran Hou ,Yingxin Chen , Fei Yang* (通讯作者). Functional role of   bloom-forming cyanobacterium Planktothrix in ecologically shaping aquatic   environments. Science of the Total Environment, 2020, 710, 136314.JCR1区,IF 10.7

8. Fei Yang (第一作者), Xiping Yi, Jian Guo, Shuaishuai Xu, Yi Xiao, Xiaoyan Huang, Yanying Duan, Dan Luo, Shuiyuan Xiao, Zhijun Huang, Hong Yuan, Meian He, Minxue Shen*, Xiang Chen*. Association of plasma and urine metals levels with   kidney function: A population-based cross-sectional study in China. Chemosphere, 2019, 226: 312-328.JCR1区,IF 8.9

9. Haohao Liu, Xin Zeng, Yueqin Wang, Michael D. Losiewicz, Xinghai Chen, Xingde Du, Yongshui Wang, Bingyu Zhang, Xing Guo, Shumeng Yuan, Fei Yang* (通讯作者), Huizhen Zhang. Chronic Exposure to Environmentally Relevant Concentrations of Microcystin-Leucine Arginine Causes Lung Barrier Damage through PP2A Activity Inhibition and Claudin1 Ubiquitination[J]. Journal of Agricultural and Food Chemistry, 2022, 70(35), 10907-10918. ( JCR 1, Top 期刊IF=5.895)

10. Haohao Liu, Xin Zeng, Ya Ma, Xinghai Chen, Michael D. Losiewicz, Xingde Du, Zhihui Tian, Shiyu Zhang, Linjia Shi, Huizhen Zhang, Fei Yang* (通讯作者). Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway[J]. Ecotoxicology and Environmental Safety, 2022, 236: 113454. (JCR 1, IF=7.129)

11. Can Du, Shuiling Zheng, Yue Yang, Xiangling Feng, Jihua Chen, Yan Tang, Hui Wang, Fei Yang* (通讯作者). Chronic exposure to low concentration of MC-LR caused hepatic lipid metabolism disorder[J]. Ecotoxicology and Environmental Safety, 2022, 239: 113649. (JCR 1, IF=7.129)

12. Shuidong Feng, Mengyue Cao, Peng Tang, Shuxiang Deng, Limou Chen, Yan Tang, Lemei Zhu, Xiang Chen, Zhijun Huang, Minxue Shen*, Fei Yang* (通讯作者). Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China. Toxins, 2023, 15(4), 293.JCR1区,IF 5.0

13. Fei Yang* (通讯作者), Jian Guo, Feiyu Huang, Isaac Yaw Massey, Ruixue Huang, Yunhui Li, Cong Wen, Ping Ding, Weiming Zeng, Geyu Liang. Removal of Microcystin-LR by a Novel Native Effective Bacterial Community Designated as YFMCD4 Isolated from Lake Taihu. Toxins, 2018, 10(9): 363.JCR1区,IF 5.0

14. Fei Yang* (第一作者), Cong Wen, Shuilin Zheng, Shu Yang, Jihua Chen, Xiangling Feng*. Involvement of MAPK/ERK1/2 pathway in microcystin-induced microfilament reorganization in HL7702 hepatocytes. Journal of Toxicology and Environmental Health, Part A. 2018, 81(21): 1135-1141.JCR2区,IF 3.2,高被引论文)

15. Ruixue Huang, Ping Ding, Dequn Huang, Fei Yang* (通讯作者). Antibiotic   pollution threatens public health in China. Lancet, 2015, 385(9970): 773-774.   JCR1区,IF 202.7

16. Isaac Yaw Massey, Xian Zhang, Fei Yang* (通讯作者). Importance of   bacterial biodegradation and detoxification processes of microcystins for   environmental health. Journal of Toxicology and Environmental Health Part B.   2018, 21(6-8): 357-369.JCR1区,IF 8.0

17. Pian Wu, Guiyin Li, Yafei He, Dan Luo, Lei Li, Jian Guo, Ping Ding*, Fei Yang* (通讯作者). High-efficient and sustainable biodegradation of microcystin-LR using Sphingopyxis sp. YF1 immobilized Fe3O4 @chitosan. Colloids and Surfaces   B-Biointerfaces, 2020, 185: 110633.JCR1区,IF 5.9,高被引论文)

18. Muwaffak Alosman, Linghui Cao, Isaac Yaw Massey, Fei Yang* (通讯作者).  The lethal effects and determinants of microcystin-LR on heart: a mini review. Toxin   Reviews. 2020,JCR2区,IF 3.1

19. Lv Chen, Shu Yang, Cong Wen, Shuilin Zheng, Yue Yang, Xiangling Feng, Jihua Chen, Dan Luo, Ran Liu, Fei Yang* (通讯作者). Regulation of Microcystin-LR-Induced DNA Damage by miR-451a in HL7702 Cells. Toxins, 2019, 11(3): 164. JCR1区,IF 5.0,高被引论文)

20. Jihua Chen, Yuji Li, Fuqiang Liu, Dexing Hou, Jingjing Xu, Xinying Zhao, Fei Yang* (通讯作者), Xiangling Feng*. Prodigiosin promotes Nrf2 activation to inhibit oxidative stress induced by Microcystin-LR in HepG2 cell. Toxins, 2019, 11(7): 403.JCR1区,IF 5.0

21. Xiping Yi#, Shuaishuai Xu#, Feiyu Huang, Cong Wen, Shuilin Zheng, Hai Feng, Jian Guo, Jihua Chen, Feng Xiangling Feng, Fei Yang* (通讯作者). Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice. International Journal of Environmental Research and Public Health, 2019, 16(24):e5030.JCR1区,IF 4.6

22. Linghui Cao, Feiyu Huang, Isaac Yaw Massey, Cong Wen, Shuilin Zheng, Shuaishuai Xu, Fei Yang* (通讯作者). Effects of Microcystin-LR on the Microstructure and Inflammation-Related Factors of Jejunum in Mice. Toxins, 2019, 11(9): 482.JCR1区,IF 5.0 热点论文+高被引论文)

23. 易细平,文聪,黄飞羽,郭健,杨飞*(通讯作者). 微囊藻毒素对人群消化系统健康影响的流行病学研究进展。环境与职业医学, 2019, 36(09): 879-883(预防医学与卫生学高质量期刊)

24. 梁小芳, 杨越, 徐帅帅, 刘映, 褚晗玉, 唐艳, 杨飞*(通讯作者).  微囊藻毒素-LR长期低剂量暴露诱导小鼠肾脏结构和功能损伤:基于激活PI3K/AKT信号通路[J]. 南方医科大学学报, 2022, 42(10): 1486-1494.(卓越期刊)

25. 王阳灿, 唐艳, 周盛祥, 邓蜀湘, 陈立谋, 沈敏学, 杨飞*(通讯作者). 血浆铀浓度与肝损伤关联性的病例-对照研究[J]. 环境与职业医学, 2022, 39(10): 1077-1082. (预防医学与卫生学高质量期刊)

26. Hao Yin, Chunyuan Chen, Yiwei Liu, Yijuan Tan, Zhili Deng, Fei Yang, Feiyu Huang, Cong Wen, Shanshan Rao, Mingjie Luo, Xiongke Hu, Zhengzhao Liu, Zhenxing Wang, Jia Cao, Haoming Liu, Jianghua Liu, Tao Yue, Siyuan Tang, Hui Xie*. Synechococcus elongatus PCC7942 secretes extracellular vesicles to accelerate cutaneous wound healing by promoting angiogenesis. Theranostics, 2019, 9(9): 2678-2693.JCR1区,IF11.6

知识产权

1. 一株新型鞘氨醇盒菌菌株及其在微囊藻毒素降解解毒领域的应用发明专利2018ZL201811512049.X

2. 一种微生物磁性壳聚糖纳米材料及其制备方法和其在微囊藻毒素降解领域的应用发明专利2018ZL201811513472.1

3. 一种自动进样固相萃取装置实用新型发明专利2018ZL2018215627654

4. 制备提纯灵菌红素的方法发明专利2011ZL201110201993.5

5. 一种多功能生物吸附材料及其制备方法发明专利2016ZL201610145125.2

6. 一种荧光磁性纳米复合材料及其制备方法,发明专利,2015ZL201510076969.1

出版著作

1.《蓝藻毒素污染与健康》,湖北科学技术出版社,2020年,参编

成果奖项

1. 湖南省检验检测科学技术奖一等奖,2022

2. 湖南省预防医学科学技术奖三等奖,2022

3. 全球前2%顶尖科学家,2022

4. 湖南省青年骨干教师2018

5. 湖南省优秀青年基金获得者2020

6. 湖湘青年科技创新人才,2022



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